Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-
Cholera Toxin B subunit
CAS: 451491-47-7
Molecular Formula: C16H13ClF3NO2
Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy- - Names and Identifiers
Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy- - Physico-chemical Properties
| Molecular Formula | C16H13ClF3NO2 |
| Molar Mass | 343.73 |
| Solubility | ethanol: 2 mg/mL |
| Appearance | powder |
| Color | white to off-white |
| Storage Condition | 2-8°C |
| Use | CTB (Cholera Toxin B subunit) is an activator of p300 histone acetyltransferase (p300 histone acetyltransferase). CTB induces apoptosis in MCF-7 cells (apoptosis). |
| Target | p300 |
Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy- - Risk and Safety
| Risk Codes | R36 - Irritating to the eyes R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 2 |
Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy- - Reference
| Reference Show more | 1. Mantelingu K, et al. Activation of p300 histone acetyltransferase by small molecules altering enzyme structure: probed by surface-enhanced Raman spectroscopy. J Phys Chem B. 2007;111(17):4527-4534.2. Dastjerdi MN, et al. The effect of CTB on P53 protein acetylation and consequence apoptosis on MCF-7 and MRC-5 cell lines. Adv Biomed Res. 2013;2:24. Published 2013 Mar 6.3. Chen X, et al. Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. Mol Neurodegener. 2020;15(1):2. Published 2020 Jan 6. |
Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.909 ml | 14.546 ml | 29.093 ml |
| 5 mM | 0.582 ml | 2.909 ml | 5.819 ml |
| 10 mM | 0.291 ml | 1.455 ml | 2.909 ml |
| 5 mM | 0.058 ml | 0.291 ml | 0.582 ml |
Last Update：2024-01-02 23:10:35
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View History
Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-
(R)-1-(4-甲氧基吡啶-2-基)乙胺二盐酸盐
9alpha-Fluoro-11beta-hydroxy-16alpha-methyl-1,4-androstadiene-3,17-dio ne
四氯钯(II)酸铵
4,5-Dihydroxy-2-anthraquinonecarboxylic Acid-13C6
5-羟基3,3′,4′,7-四甲氧基黄酮
3-氯-5-硝基苯甲醛
oleic acid, compound with 2-(2-aminoethoxy)ethanol (1:1)
1-[(2,3-Dichlorophenyl)carbonyl]piperidine
1-[3,5-bis(trifluoromethyl)phenyl]-1,4,5,6,7,8-hexahydrocyclohepta[c]pyrazole-3-carboxylic acid
(R)-1-(4-甲氧基吡啶-2-基)乙胺二盐酸盐
9alpha-Fluoro-11beta-hydroxy-16alpha-methyl-1,4-androstadiene-3,17-dio ne
四氯钯(II)酸铵
4,5-Dihydroxy-2-anthraquinonecarboxylic Acid-13C6
5-羟基3,3′,4′,7-四甲氧基黄酮
3-氯-5-硝基苯甲醛
oleic acid, compound with 2-(2-aminoethoxy)ethanol (1:1)
1-[(2,3-Dichlorophenyl)carbonyl]piperidine
1-[3,5-bis(trifluoromethyl)phenyl]-1,4,5,6,7,8-hexahydrocyclohepta[c]pyrazole-3-carboxylic acid